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. 2015 Aug 20;14(6):957–970. doi: 10.1111/acel.12387

Figure 2.

Figure 2

Butyrate prevents muscle atrophy during aging. (A) Hindlimb muscle mass of 12 and 26‐month‐old C57Bl/6 female mice relative to body weight (n = 14–17). (B) Cross‐sectional area and (C) minimum Feret's diameter (n = 3) from muscle sections stained with hematoxylin and treosin. (D) Four‐paw grip strength (n = 5–8). (E) Muscle fiber type determined by MHC isoform composition (n = 3–4). (F) Representative images used to quantify CSA and MFD (*P < 0.05 vs. diet‐matched young; # P < 0.05 vs. age‐matched control; control young – white, control aged – black, butyrate young – light gray, butyrate aged – dark gray). (G) Oil Red O staining of lipid droplets in gastrocnemius muscle (Sections from three animals were examined per group; 4× and 10× images are from two different animals per group). All data are displayed as means with standard error.