Table 1.
Morphometric analysis of dystrophy progression in mdx diaphragm (DIA) and quadriceps (QDR) muscles. Indicated are areas containing fibres with peripheral cell nuclei (Peripheral nuclei), areas with centrally nucleated fibres completely regenerated (Central nuclei), areas with clusters of fibres under regeneration (Regeneration) and areas with fibrosis (Fibrosis), at 1, 4 and 9 months of age
| 1 | 4 | 9 | ||||
|---|---|---|---|---|---|---|
| DIA | QDR | DIA | QDR | DIA | QDR | |
| Peripheral nuclei | 88.6 ± 1.4* | 61.3 ± 2.3* | 74.5 ± 2.2 | 7.8 ± 2.9† | 66.2 ± 2.0 | 1.0 ± 0.5 |
| Central nuclei | 1.7 ± 0.09* | 9.9 ± 1.4* | 25.5 ± 2.2 | 79.3 ± 2.5 | 33.8 ± 2.0 | 90.4 ± 1.9 |
| Regeneration | 1.1 ± 0.6* | 22.9 ± 1.1* | 2.2 ± 0.4† | 7.1 ± 1.8 | 4.7 ± 0.3 | 3.5 ± 0.9 |
| Fibrosis | 1.8 ± 0.1* | 0.5 ± 0.1 | 18.2 ± 2.5† | 0.6 ± 0.2 | 32.3 ± 7.4 | 0.6 ± 0.1 |
Values are expressed as the percentage (mean ± SD) of the total cross‐sectional area. *Significantly different from 4 and 9 months of age; †Significantly different from 9 months of age (P < 0.05, anova).