Table 1.

Prevalence of hypocitraturia in patients starting topiramate. Data show mean ± SD for 24 h urinary parameters related to stone risk. Time points shown are before topiramate (baseline) and at 30 and 60 days after starting topiramate. P values‡ for differences between time points are shown at the right for each parameter. Significant differences (P ≤ 0.05) are in bold and denoted with an asterisk

	Baseline	30 days	60 days	Baseline vs. 30 days	Baseline vs. 60 days	30 vs. 60days
Volume (l)	1.33 ± 0.67	1.57 ± 0.98	1.64 ± 0.84	0.52	0.37	0.88
pH	6.13 ± 0.44	6.60 ± 0.50	6.53 ± 0.27	*0.046	*0.022	0.71
Calcium (mg)	160 ± 116	180 ± 109	197 ± 131	0.71	0.52	0.78
Oxalate (mg)	28 ± 6.2	25 ± 8.6	32 ± 15	0.42	0.37	0.26
Uric acid (mg)	474 ± 198	514 ± 178	470 ± 135	0.65	0.96	0.58
Citrate (mg)	526 ± 280	279 ± 121	218 ± 82	*0.016	*0.0032	0.27
Sodium (mEq)	136 ± 82	141 ± 63	155 ± 63	0.88	0.58	0.66
Sulfate (mmol)	15 ± 8.2	15 ± 6.9	16 ± 6.8	0.97	0.94	0.91
Phosphorus (mg)	925 ± 366	791 ± 275	759 ± 305	0.39	0.30	0.83
Magnesium (mg)	94 ± 42	91 ± 48	107 ± 67	0.89	0.59	0.59
Ammonium (mEq)	26 ± 11	26 ± 7.7	27 ± 13	0.97	0.80	0.82
Potassium (mEq)	50 ± 28	47 ± 18	46 ± 18	0.80	0.68	0.86
Creatinine (mg)	1381 ± 518	1371 ± 445	1411 ± 544	0.96	0.90	0.88
CaOx SS†	1.70 ± 0.70	1.61 ± 0.74	1.99 ± 1.2	0.78	0.50	0.46
Brushite SS	2.07 ± 1.3	2.95 ± 0.88	2.76 ± 1.2	0.11	0.24	0.72
Struvite SS	2.00 ± 2.6	5.23 ± 3.5	3.59 ± 2.0	0.040	0.18	0.27
Uric acid SS	1.77 ± 1.7	0.86 ± 1.1	0.52 ± 0.34	0.16	*0.029	0.42

^†SS, relative supersaturation.

^‡Where data plots revealed unequal variance, a t‐test assuming unequal variance was used to assess statistical difference.