Figure 1.

Hypomyelination secondary to loss of Tsc2 from oligodendrocytes. Sudan black and MBP immunofluorescence staining of P70 control and Olig2‐CKO brains demonstrates diffuse decreases in myelin (A, B). Cortical expression of the myelin proteins MBP, MAG, and CNPase are significantly decreased in P70 cortex (C, D). Activation of mTORC1 signaling (pS6) and attenuation of mTORC2 (pNDRG1) signaling is seen with increased S6 phosphorylation and decreased NDRG1 phosphorylation, respectively. n = 3–6 animals per group. **P < 0.01. MBP, myelin basic protein; CKO, conditional knockout; MAG, myelin‐associated glycoprotein; CNPase, 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase; NDRG1, N‐Myc downstream regulated 1.