Figure 2.

Decreased fractional anisotropy and myelin total water fraction following loss of Tsc2. P60 control and Tsc2‐Olig2 CKO mice were imaged ex vivo with a 15.2T MRI scanner. Traditional T₂‐weighted imaging for anatomical reference (A). Fractional anisotropy was decreased (B) secondary to increases in radial diffusivity (C). The myelin water fraction, a more specific marker for myelin quantity, is also significantly reduced, consistent with hypomyelination (D). n = 5 animals per group. **P < 0.01, ***P < 0.001. CKO, conditional knockout; MRI, magnetic resonance imaging.