Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 27;2(12):1041–1054. doi: 10.1002/acn3.254

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Decreased myelin density and myelin thickness in Tsc2‐Olig2 CKO. Electron micrographs from P60 littermate control (A) and Tsc2‐Olig2 CKO (B) CC demonstrate a decreased density of myelinated axons in CKO (C) brains as well as a reduction in the myelin volume fraction (D). Scale bar = 500 nm. Myelin thickness is decreased as demonstrated by an increased G ratio in Tsc2‐Olig2 CKO CC (E). G ratio plotted as a function of axon diameter bins (F). n > 50 axons from three animals per genotype. ***P < 0.001 by Student's t‐test. CKO, conditional knockout; CC, corpus callosum.