. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Neuropsychology. 2016 Jan;30(1):40–52. doi: 10.1037/neu0000244

Table 2.

Heritability Estimates and Statistical Associations between Gene Expression, CVLT, and Diagnostic Status

		Swedish Discovery Sample									Finnish Replication Sample

		Association with CVLT				Association with Diagnosis				Heritability	Association with Diagnosis
Illumina Probe	Gene Symbol	t	df	p_Bon	Partial R²	F	df	p	Partial R²	h²	F	df	p	Partial R²
ILMN_1752111	SMARCAL1	5.15	171.82	0.013	0.134	6.26	2, 61	0.003	0.078	0.47	1.95	2, 42	0.155	0.046
ILMN_2224143	MCM3	5.35	167.21	0.005	0.146	6.25	2, 61	0.003	0.080	0.47	2.61	2, 42	0.085	0.062
ILMN_1728298	SBK1	5.03	178.74	0.022	0.124	6.07	2, 61	0.004	0.075	0.33	2.78	2, 42	0.073	0.063
ILMN_1777740	THEM6	5.02	183.32	0.023	0.121	5.99	2, 61	0.004	0.075	0.47	2.25	2, 42	0.118	0.055
ILMN_1750800	ACO1	5.33	174.07	0.006	0.140	5.81	2, 61	0.005	0.075	0.54	1.98	2, 42	0.151	0.047
ILMN_2073012	TMEM203	5.06	173.37	0.020	0.128	5.75	2, 61	0.005	0.075	0.35	2.19	2, 42	0.124	0.049
ILMN_1676745	ZNF142	5.32	187.98	0.005	0.131	5.74	2, 61	0.005	0.074	0.48	2.06	2, 42	0.141	0.048
ILMN_1787461	RUNX3	5.46	186.37	0.003	0.138	5.49	2, 61	0.006	0.068	0.00	2.59	2, 42	0.087	0.059
ILMN_1775522	MAGED1	6.14	178.43	< .0001	0.174	5.32	2, 61	0.007	0.073	0.52	3.02	2, 42	0.060	0.072
ILMN_2412549	GAR1	5.31	173.46	0.006	0.140	5.26	2, 61	0.008	0.070	0.45	2.74	2, 42	0.076	0.064
ILMN_1689953	CD81	5.49	183.50	0.002	0.141	5.22	2, 61	0.008	0.066	0.41	1.45	2, 42	0.245	0.034
ILMN_1701731	AKR1B1	5.04	182.99	0.021	0.122	4.86	2, 61	0.011	0.065	0.41	1.88	2, 42	0.165	0.042
ILMN_1686871	PARP1	5.70	168.60	0.001	0.161	4.68	2, 61	0.013	0.060	0.40	2.49	2, 42	0.095	0.060
ILMN_1786024	POLR3H	5.01	182.79	0.024	0.121	4.56	2, 61	0.014	0.049	0.58	2.41	2, 42	0.102	0.058
ILMN_1733696	IMP3	5.32	164.72	0.006	0.147	4.56	2, 61	0.014	0.058	0.24	1.82	2, 42	0.174	0.042
ILMN_1721978	CARD11	5.27	183.58	0.007	0.131	4.44	2, 61	0.016	0.050	0.46	2.86	2, 42	0.069	0.068
ILMN_1700604	RBM14	4.88	172.74	0.045	0.121	4.41	2, 61	0.016	0.052	0.31	1.38	2, 42	0.262	0.034
ILMN_2097793	ZBTB4	5.32	177.36	0.006	0.138	4.38	2, 61	0.017	0.056	0.25	2.52	2, 42	0.092	0.059
ILMN_1673991	ATIC	5.92	187.94	< .0001	0.157	4.28	2, 61	0.018	0.056	0.34	3.09	2, 42	0.056	0.071
ILMN_1766010	YARS	5.31	172.45	0.006	0.140	4.21	2, 61	0.019	0.053	0.44	2.67	2, 42	0.081	0.063
ILMN_2162989	TMEM189	4.88	187.02	0.042	0.113	4.12	2, 61	0.021	0.049	0.53	1.69	2, 42	0.197	0.041
ILMN_1665943	MAP4K1	5.29	187.88	0.006	0.130	4.10	2, 61	0.021	0.054	0.38	2.00	2, 42	0.149	0.046
ILMN_2334296	IL18BP	5.18	187.67	0.011	0.125	4.08	2, 61	0.022	0.046	0.50	2.15	2, 42	0.129	0.047
ILMN_2044453	LPAR5	4.96	187.39	0.029	0.116	4.05	2, 61	0.022	0.053	0.51	1.22	2, 42	0.305	0.030
ILMN_2153787	ARRDC5	4.87	185.73	0.043	0.113	4.03	2, 61	0.023	0.055	0.54	1.85	2, 42	0.169	0.046
ILMN_1788538	NCALD	4.99	187.95	0.025	0.117	3.89	2, 61	0.026	0.050	0.47	2.23	2, 42	0.120	0.055
ILMN_1670948	TSR2	4.98	185.88	0.026	0.118	3.77	2, 61	0.029	0.048	0.42	1.67	2, 42	0.201	0.039
ILMN_1671257	DKC1	5.33	169.07	0.006	0.144	3.69	2, 61	0.031	0.050	0.45	1.87	2, 42	0.167	0.045
ILMN_1663954	NELFCD	5.18	185.13	0.011	0.127	3.68	2, 61	0.031	0.053	0.49	2.32	2, 42	0.111	0.054
ILMN_1761479	ZC3HC1	5.49	156.95	0.003	0.161	3.60	2, 61	0.033	0.046	0.52	2.23	2, 42	0.120	0.053
ILMN_2183687	LIME1	4.98	183.23	0.027	0.119	3.60	2, 61	0.033	0.045	0.00	1.97	2, 42	0.152	0.050
ILMN_1801348	GOT2	5.15	178.21	0.013	0.129	3.54	2, 61	0.035	0.044	0.51	2.78	2, 42	0.073	0.062
ILMN_1779185	SPECC1L	4.99	162.99	0.028	0.133	3.46	2, 61	0.038	0.042	0.42	2.28	2, 42	0.115	0.052
ILMN_1753885	YTHDF1	5.05	185.90	0.019	0.121	3.38	2, 61	0.040	0.046	0.29	1.91	2, 42	0.161	0.046
ILMN_1740265	ACOT7	4.96	185.07	0.029	0.117	3.38	2, 61	0.041	0.044	0.49	2.32	2, 42	0.111	0.054
ILMN_2306189	MAGED1	4.99	187.34	0.025	0.117	3.36	2, 61	0.041	0.050	0.50	2.66	2, 42	0.082	0.065
ILMN_1748894	GTPBP3	4.87	173.16	0.047	0.120	3.35	2, 61	0.042	0.044	0.49	2.48	2, 42	0.096	0.059
ILMN_1685580	CBLB	5.47	184.39	0.003	0.140	3.33	2, 61	0.042	0.043	0.57	2.34	2, 42	0.109	0.058
ILMN_2343097	NCALD	5.12	188.00	0.014	0.122	3.33	2, 61	0.043	0.044	0.43	2.47	2, 42	0.097	0.062
ILMN_1708328	RAB11FIP3	5.01	185.32	0.023	0.119	3.32	2, 61	0.043	0.044	0.52	2.11	2, 42	0.134	0.050
ILMN_1751338	NUP133	5.20	167.84	0.011	0.139	3.31	2, 61	0.043	0.047	0.49	2.01	2, 42	0.146	0.047
ILMN_1744068	ELP3	5.25	173.50	0.008	0.137	3.20	2, 61	0.048	0.043	0.51	1.90	2, 42	0.162	0.043
ILMN_1763460	NHP2L1	5.02	183.07	0.022	0.121	3.19	2, 61	0.048	0.041	0.27	1.80	2, 42	0.179	0.039

Note. Seventy-six genes were associated with CVLT after correcting for multiple comparisons (p < 2.69 × 10⁻⁶) and, of those, 43 were also associated with diagnostic status (p < .05). For CVLT- and diagnosis-associated genes, the effect of each probe on CVLT adjusted for age and sex in the discovery sample, as well as the overall effect of diagnosis on each probe in both samples, is reported. Broad heritability estimates from best fitting models are listed as well. Italics denote heritability models where the chi-square was not significant, indicating good model fit. For all but four of the heritable genes (IMP3, ZBTB4, NHP2L1, YTHDF1), removal of the genetic term resulted in a significant decrement in model fit, p < .05.