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. 2015 Sep 19;2(11):987–1001. doi: 10.1002/acn3.245

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© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Long‐term high‐dose enzyme replacement therapy (ERT) attenuates microgliosis in most parts of the brain. (A) Immunofluorescence of brain sections using the glial marker CD68 and GFAP reveals less activation of CD68 positive microglia after long‐term ERT (14 weeks) with biweekly injections of 500 U/kg in the hippocampus, cerebral cortex and thalamus. In the cerebellum, no obvious change in the presence of activated microglia (A, lower panel) or GFAP positive Bergman glia (B) is evident (Scale bar: A, 50 μm; B, 100 μm). In (A) representative z stack images with maximum projection are shown.