Table 1.
Study group characteristics
| AutoAb (%positive) (U/ml mean ± SE)2 | |||||||
|---|---|---|---|---|---|---|---|
| Groups | Total subject number | Mean age (years) ± SE | FPG (mg/dl) ± SE1 | HbA1c (%) ± SE (mmol/mol) | GAD65a | IA2b | Insulinc |
| Newly diagnosed type 1 diabetics | 69 | 9.6 ± 0.5 | 115.4 ± 7.6 | 8.4 ± 0.3 (68 ± 3.3) | 37.7 (28.4 ± 8.5) | 40.6 (126.5 ± 28.5) | 30.4 (7.1 ± 1.9) |
| Siblings | 76 | 13.2 ± 0.7 | 85.7 ± 0.8 | 5.3 ± 0.7 (34 ± 7.7) | 32.9 (7.1 ± 1.9) | 7.9 (8.45 ± 5.6) | 10.5 (1.2 ± 0.5) |
| Parents | 116 | 38.4 ± 0.8 | 109 ± 5.6 | 5.9 ± 0.2 (41 ± 2.2) | 10.3 (2.5 ± 0.7) | 6 (5.4 ± 4) | 9.5 (1.2 ± 0.4) |
| Normal controls | 53 | 9.8 ± 0.6 | 85.7 ± 1.3 | 5.4 ± 0.05 (36 ± 0.5) | 3.7 (1.7 ± 1) | 1.8 (0.4 ± 0.2) | 15.1 (4.3 ± 2) |
| Sibling controls | 20 | 13.1 ± 1.0 | 86.9 ± 2.2 | 5.2 ± 0.1 (33 ± 1.1) | 15 (3.3 ± 2.1) | 0 (0.2 ± 0.2) | 10 (3 ± 1.5) |
| Parent controls | 57 | 38.2 ± 1.0 | 97.0 ± 4.2 | 6.5 ± 0.7 (48 ± 7.7) | 22.8 (5.9 ± 1.7) | 0 (0.2 ± 0.1) | 19.3 (2.4 ± 0.7) |
1
FPG, Fasting plasma glucose = 126 mg/dl was considered diagnostic of diabetes.
2
Auto‐antibodies were determined by ELISA. Positive values: a = 5.0 UI/mL; b = 7.5 UI/mL; c > 1.05 U/ml.