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. 2015 Sep 17;3(4):420–430. doi: 10.1002/iid3.80

Figure 1.

Figure 1

Loss of IL‐4Rα‐PI3K signaling accelerates progression of an anaphylactic reaction. A: Diarrhea occurrence in OVA‐sensitized, intragastric (i.g.) OVA‐challenged WT and IL‐4RαY500F mice. B: Temperature change from 0 to 60 min and C: 0, 15, 30, and 45 min following the seventh intragastric (i.g.) OVA challenge in OVA‐sensitized, OVA‐challenged WT and IL‐4RαY500F mice. D: Mast cell (MC) numbers per high power field (HPF) in the small intestine, OVA‐specific IgE (E) and mast cell protease 1 (MCPT‐1), (F) levels in the serum of OVA‐sensitized, OVA‐challenged WT and IL‐4RαY500F mice following the seventh challenge. A: Data are presented as a percentage of diarrhea occurrence after a number of OVA challenges. The fraction indicates the number of mice with diarrhea out of the total number of mice in that group. (B, D–F: Individual circles represent 1 mouse). B: Red circles represent identification of positive intestinal symptoms of anaphylaxis (diarrhea), and black circles represent no evidence of intestinal symptoms of anaphylaxis. B–F: Data represent mean ± SD; n = 4–18 mice per group; P values as indicated. O.D., optical density.