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Effect of the mutation of all three TonB systems on the lethality to mice
| Infection and mouse type | LD50 (95% confidence limits) |
Fold increase | |
|---|---|---|---|
| WT | ΔtonB123 mutant | ||
| Intragastric | |||
| Suckling | 1.26 × 105 (2.16 × 104 to 4.82 × 105) | 5.23 × 106 (3.32 × 105 to 9.95 × 107) | 41.62 |
| Intraperitoneal | |||
| Normal | 3.15 × 105 (8.38 × 104 to 1.13 × 106) | 8.12 × 106 (2.04 × 106 to 3.1 × 107) | 25.78 |
| Iron overloaded | 2.125 | 2.125 | 1 |
