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Reactivation of J-PPD-specific IFN-γ responses by LAG-3 blockade. Whole blood cells were cultured with blocking MAbs (anti-PD-1, anti-PD-L1, and anti-LAG-3 MAbs; 10 μg/ml) or rat IgG control in the presence of J-PPD (5 μg/ml). IFN-γ production in plasma was measured using ELISA (uninfected, n = 3; infected, n = 7). Comparisons of blocking MAbs in animal groups were performed using Tukey's test. Differences were considered significant when P < 0.05, indicated by an asterisk.
