Table 1. Dose Level Summary.
| Dose Level (mg/m2) | # Patients | # Patients w/ Crs 1, Grd 3/4 Tox | # Patients w/ Crs 1, Grade 3/4 Tox Related | Patients w/ DLT | Total Completed Courses (# pts) | Objective Responses |
|---|---|---|---|---|---|---|
| 0.125 | 1 | 0 | 0 | 0 | 2 (1) | |
|
| ||||||
| 0.18 | 0 | |||||
| 0.25 | 1 | 0 | 0 | 0 | 8 (1) | |
| 0.35 | 0 | |||||
| 0.5 | 7 | 4 | 2 (Lymphopenia (1)) | 1 (Alkaline Phosphatase) | 12 (7) | |
| 0.7 | 4 | 3 | 2 | 0 | 14 (4) | |
| 1.0 | 3 | 1 | 0 | 0 | 5 (3) | |
| 1.4 | 19 | 14 | 10 | 1 (Febrile Neutropenia) | 80 (19) | PR: Lung, Bladder, Melanoma |
| 2.0 | 5 | 4 | 4 | 2 (Febrile Neutropenia) | 21 (5) | PR: Lung |
PR: Partial Response; Crs: Course