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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Cancer Res. 2015 Apr 3;75(11):2375–2386. doi: 10.1158/0008-5472.CAN-14-3076

Figure 6.

Figure 6

Overexpression of LEP, p-STAT3, and OBR is correlated with H3k9Me2-mediated silencing of miR-200c in poorly differentiated and triple-negative breast cancer. A, representative images showing expression levels of LEP, p-STAT3, miR-200c, and OBR in 98 human breast tissue specimens (scale bar, 100 μm). B, χ2 analysis of expression levels of LEP, p-STAT3, miR-200c, and OBR in 98 human breast tissue specimens, including benign and low-grade tumors (≤ tumor grade I) and high-grade tumors (tumor grades II-III). −, negative staining; +, positive staining. The association of STAT3-G9a (C) and H3K9Me2 (D) to MiR-200c promoter, and expression level of miR-200c (E) and the percentage of CD24−CD44+ cells (F) in luminal or TNBC (n = 11 in each group). Error bars, ±SD.