Table 2.
(A) | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | SNP | MAF‐NAFLD cases | MAF‐controls | OR | P‐value | MAF‐Bronx population | OR | P‐value | MAF‐general population | RR | P‐value | MAF‐Puerto Rican population | OR | P‐value |
CHUK | rs11597086 | 26% (22/15/3) | 16% (15/7/0) | 1.65 | 0.35 | 23% (134/75/14) | 1.14 | 0.67 | 22% (694/308/90) | 1.18 | 0.55 | 43% (19/25/11) | 0.61 | 0.09 |
ENPP1 | rs1044498 | 37% (19/11/9) | 42% (10/8/6) | 0.89 | 0.72 | 36% (105/80/42) | 1.03 | 0.90 | 29% (660/224/208) | 1.27 | 0.29 | 19% (37/15/3) | 1.96 | 0.05 |
ERLIN1 | rs2862954 | 29% (20/14/4) | 14% (15/6/0) | 2.03 | 0.20 | 26% (127/69/22) | 1.12 | 0.70 | 25% (665/314/113) | 1.17 | 0.55 | 48% (15/27/13) | 0.60 | 0.07 |
PNPLA3 | rs738409 | 56% (9/17/14) | 19% (16/7/1) | 2.95 | 0.003 | 19% (139/62/8) | 3.01 | 4.4E‐7 | 28% (590/382/120) | 1.97 | 0.0001 | 36% (20/30/5) | 1.56 | 0.05 |
PNPLA3 | rs2896019 | 41% (17/13/10) | 17% (17/6/1) | 2.48 | 0.04 | 25% (132/75/20) | 1.63 | 0.04 | 28% (604/374/114) | 1.50 | 0.06 | 28% (27/25/3) | 1.47 | 0.18 |
SAMM50 | rs3761472 | 38% (17/14/8) | 17% (16/8/0) | 2.31 | 0.07 | 21% (146/68/14) | 1.83 | 0.02 | 25% (628/374/90) | 1.52 | 0.07 | 21% (33/21/1) | 1.83 | 0.06 |
SAMM50 | rs2143571 | 44% (14/16/9) | 25% (13/10/1) | 1.74 | 0.14 | 28% (120/88/20) | 1.55 | 0.05 | 32% (514/453/125) | 1.35 | 0.14 | 30% (25/27/3) | 1.45 | 0.18 |
ABCC2 | rs17222723 | 10% (31/8/0) | 2% (23/1/0) | 4.92 | 0.22 | 7% (193/33/0) | 1.40 | 0.52 | 4% (1000/91/1) | 2.40 | 0.08 | 7% (47/8/0) | 1.47 | 0.57 |
(B) | ||||||||
---|---|---|---|---|---|---|---|---|
MAF‐Bronx population | MAF‐general population | OR | P‐value | MAF‐Puerto Rican population | OR | P‐value | ||
CHUK | rs11597086 | 23% | 22% | 1.04 | 0.79 | 43% | 0.54 | 0.003 |
ENPP1 | rs1044498 | 36% | 29% | 1.24 | 0.04 | 19% | 1.90 | 0.02 |
ERLIN1 | rs2862954 | 26% | 25% | 1.05 | 0.69 | 48% | 0.54 | 1.5E‐3 |
PNPLA3 | rs738409 | 19% | 28% | 0.66 | 3.5E‐3 | 36% | 0.52 | 5.2E‐4 |
PNPLA3 | rs2896019 | 25% | 28% | 0.92 | 0.49 | 28% | 0.90 | 0.68 |
SAMM50 | rs3761472 | 21% | 25% | 0.83 | 0.17 | 21% | 1.00 | 0.98 |
SAMM50 | rs2143571 | 28% | 32% | 0.87 | 0.22 | 30% | 0.94 | 0.78 |
ABCC2 | rs17222723 | 7% | 4% | 1.71 | 0.05 | 7% | 1.04 | 0.94 |
NAFLD, nonalcoholic fatty liver disease; SNP, single‐nucleotide polymorphisms.