Table 1.

Exosome and exosomal cargo as biomarkers or therapeutics of HCC

	Sample type	Exosome or exosomal cargo	Outcome	Reference
HCC patients with LT	Serum	miR-718	Biomarker for HCC recurrence and prognosis	[52]
HCC/Hepattis B patients	Serum	miR-221, miR191, miR-181a and miR-26a	Biomarker for early-stage HCC diagnosis	[53]
HCC rats	Serum	Exosome	Biomarker for early-stage HCC diagnosis	[54]
HCC patients	Serum	miR-21	Biomarker for HCC diagnosis	[55]
HCC patients	Serum	miR-27b-3p, miR-92a-3p	Targets of HCC therapy	[56]
HCC cell lines	Cell culture medium	Exosome	miRNA transfer and contribute to HCC metastases	[57]