Table 3.
No. of study | G vs. C | GG vs. CC | GG+CG vs. CC | GG vs. CG+CC | CG vs. CC | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
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OR (95% CI) | P | P (Q-test) | OR (95% CI) | P | P (Q-test) | OR (95% CI) | P | P (Q-test) | OR (95% CI) | P | P (Q-test) | OR (95% CI) | P | P (Q-test) | ||
Total | 23 | 0.78 (0.69-0.89) | < 0.001 | 0.458 | 0.66 (0.43-1.02) | 0.060 | 0.962 | 0.77 (0.68-0.89) | < 0.001 | 0.229 | 0.70 (0.46-1.07) | 0.098 | 0.947 | 0.79 (0.68-0.91) | 0.001 | 0.122 |
Ethnicity | ||||||||||||||||
Asians | 7 | 0.72 (0.59-0.88) | 0.001 | 0.112 | 0.69 (0.36-1.32) | 0.264 | 0.834 | 0.73 (0.50-1.06) | 0.102 | 0.051 | 0.74 (0.39-1.41) | 0.353 | 0.788 | 0.75 (0.49-1.13) | 0.165 | 0.032 |
Caucasians | 16 | 0.83 (0.71-0.97) | 0.019 | 0.842 | 0.64 (0.37-1.14) | 0.128 | 0.871 | 0.83 (0.70-0.99) | 0.033 | 0.720 | 0.67 (0.38-1.18) | 0.167 | 0.849 | 0.85 (0.71-1.01) | 0.071 | 0.595 |
HWE | ||||||||||||||||
Yes | 18 | 0.76 (0.66-0.88) | < 0.001 | 0.493 | 0.81 (0.46-1.45) | 0.481 | 0.980 | 0.74 (0.63-0.86) | < 0.001 | 0.288 | 0.87 (0.49-1.54) | 0.623 | 0.977 | 0.73 (0.62-0.86) | < 0.001 | 0.206 |
No | 5 | 0.84 (0.66-1.06) | 0.134 | 0.217 | 0.52 (0.27-0.99) | 0.047 | 0.557 | 0.89 (0.69-1.16) | 0.392 | 0.163 | 0.54 (0.29-1.02) | 0.059 | 0.508 | 0.97 (0.73-1.29) | 0.854 | 0.121 |
HWE: Hardy-Weinberg equilibrium. Bold values are statistically significant (P < 0.05).