Table 2.
Results of overall and stratified analyses for the association of rs4977756 polymorphism and risk of glioma
| Viarables | Number | Homozygote (GG vs. AA) | Heterozygote (AG vs. AA) | Recessive model (GG vs. AG+AA) | Dominant model (GG+AG vs. AA) | Additive model (G vs. A) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|
|||||||
| OR (95% CI) | Ph | OR (95% CI) | Ph | OR (95% CI) | Ph | OR (95% CI) | Ph | OR (95% CI) | Ph | ||
| Total | 12 (6871/12022) | 1.55 (1.42, 1.69) | 0.996 | 1.20 (1.12, 1.28) | 0.934 | 1.39 (1.28, 1.50) | 0.995 | 1.29 (1.21, 1.37) | 0.923 | 1.24 (1.19, 1.30) | 0.966 |
| Ethnicity | |||||||||||
| European | 11 (6645/11771) | 1.56 (1.43, 1.70) | 0.999 | 1.21 (1.13, 1.30) | 0.972 | 1.39 (1.29, 1.51) | 0.994 | 1.30 (1.21, 1.38) | 0.988 | 1.25 (1.19, 1.30) | 0.997 |
| Asian | 1 (226/251) | 1.09 (0.52, 2.32) | - | 1.20 (1.12, 1.28) | - | 1.12 (0.53, 2.34) | - | 0.96 (0.66, 1.39) | - | 0.99 (0.73, 1.34) | - |
| Source of controls | |||||||||||
| Population-based | 9 (3965/5516) | 1.53 (1.35, 1.73) | 0.973 | 1.20 (1.10, 1.32) | 0.890 | 1.36 (1.22, 1.51) | 0.976 | 1.28 (1.17, 1.42) | 0.823 | 1.23 (1.16, 1.31) | 0.884 |
| Hospital-based | 3 (2906/6506) | 1.58 (1.38, 1.79) | 0.954 | 1.20 (1.12, 1.28) | 0.934 | 1.39 (1.28, 1.50) | 0.993 | 1.29 (1.21, 1.37) | 0.923 | 1.24 (1.19, 1.30) | 0.879 |
Ph P-value of Q-test for heterogeneity test. Fix-effects model was used when P-value for heterogeneity test >0.05; otherwise, random-effects model was used.