Table 3.
Tissue and plasma pharmacokinetic parameters after administration of nuciferine
| Parameters | Plasma | Brain | Kidney | Lung | Spleen | Liver | Heart | |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| iv 2 mg/kg | ig 15 mg/kg | ig 15 mg/kg | ||||||
| AUC(0-t) (ng/mL*h) | 144.8 ± 31.9 | 769.8 ± 299.7 | 4978.8 ± 480.1 | 10621.9 ± 928.7 | 3776.3 ± 968.4 | 5504.6 ± 571.0 | 9577.4 ± 1341.6 | 3186.9 ± 272.1 |
| AUC(0-∞) (ng/mL*h) | 155.0 ± 50.5 | 780.4 ± 310.3 | 5680.9 ± 1 594.7 | 17152.1 ± 13309.2 | 4411.1 ± 489.8 | 5858.2 ± 673.5 | 11879.9 ± 454.9 | 3809.5 ± 1459.4 |
| t1/2 (h) | 1.2 ± 1.0 | 3.8 ± 1.1 | 4.7 ± 4.3 | 3.9 ± 0.3 | 4.8 ± 3.2 | 3.4 ± 0.6 | 4.2 ± 2.4 | 3.7 ± 2.8 |
| Tmax (h) | 0.08 | 1.1 ± 0.4 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.6 ± 0.2 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.0 |
| CL (L/h/kg) | 13.8 ± 3.7 | 22.5 ± 10.4 | 2.8 ± 0.6 | 1.2 ± 0.5 | 3.8 ± 1.5 | 2.6 ± 0.3 | 1.4 ± 0.4 | 4.3 ± 1.1 |
| V (L/kg) | 20.7 ± 8.7 | 120.0 ± 53.2 | 16.3 ± 9.1 | 9.4 ± 3.8 | 22.4 ± 9.0 | 12.6 ± 1.8 | 7.5 ± 1.9 | 19.1 ± 7.7 |
| Cmax (ng/mL) | 131.4 ± 20.0 | 208.4 ± 99.7 | 2861.0 ± 781.4 | 6052.0 ± 1452.3 | 2154.3 ± 1570.9 | 3095.4 ± 575.0 | 5398.8 ± 911.3 | 2262.6 ± 485.9 |