Table 3.
Logistic regression analyses of associations between CTLA4 rs231775 G>A, polymorphism and risk of ESCC
| Genotype | Cases (n=629) | Controls (n=686) | Crude OR (95% CI) | P | Adjusted ORa (95% CI) | P | ||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| n | % | n | % | |||||
| CTLA4 rs231775 G>A | ||||||||
| GG | 307 | 50.83 | 310 | 46.69 | 1.00 | 1.00 | ||
| GA | 254 | 42.05 | 296 | 44.58 | 0.87 (0.69-1.09) | 0.223 | 0.85 (0.68-1.08) | 0.189 |
| AA | 43 | 7.12 | 58 | 8.73 | 0.75 (0.49-1.15) | 0.182 | 0.70 (0.45-1.07) | 0.100 |
| GA+AA | 297 | 49.17 | 354 | 53.31 | 0.85 (0.68-1.06) | 0.141 | 0.83 (0.66-1.04) | 0.100 |
| GG+GA | 561 | 92.88 | 606 | 91.27 | 1.00 | 1.00 | ||
| AA | 43 | 7.12 | 58 | 8.73 | 0.80 (0.53-1.21) | 0.289 | 0.75 (0.49-1.14) | 0.177 |
| G allele | 868 | 71.85 | 916 | 68.98 | 1.00 | |||
| A allele | 340 | 28.15 | 412 | 31.02 | 0.87 (0.73-1.03) | 0.114 | ||
a
Adjusted for age, sex, smoking and drinking status.