Thyroxine and donepezil regulated the expression of syt-1 and SNAP-25 protein in the dorsal hippocampus of adult hypothyroid rats. A, B. Western blot analysis towards the expressions of syt-1 and SNAP-25 protein in the dorsal hippocampus of CON, Hypo, T4, DON, and T4+DON groups (n=8). C, D. Quantification analysis towards the relative protein levels in each group. The data were shown as mean ± SEM. CON, Control group; Hypo, hypothyroid group; T4, hypothyroid rats treated with 5 µg T4/100 g BW; DON, hypothyroid rats treated with 0.005% (w/v) DON in drinking water; T4+DON, hypothyroid rats treated with 5 µg T4/100 g BW and 0.005% (w/v) DON in drinking water. *P<0.05, **P<0.01 vs. the Control group.