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. 2015 Oct 15;8(10):18765–18771.

Figure 2.

Figure 2

Down-regulated RASAL2 promoted migration and invasion via EMT induction in nasopharyngeal carcinoma. A. RASAL2 reduced the migration capability in CNE-1 cells with siRNA treatment compared with scramble sequence treatment by wound healing assay. The rate of cell migration was shown in the right panel. Data are presented as the mean ± SEM based on at least three independent experiments. *, indicated P<0.05. B. RASAL2 decreased the cell invasion by transwell invasion assay. Cell morphology graph of invasive cells in CNE-1 cells after transfection of siRNA or scramble. The number of cells invasion was shown in the right panel and data are presented as the mean ± SEM based on at least three independent experiments. *, indicated P<0.05. C. Western blot assay suggested that down-regulated RASAL2 decreased levels of E-cadherin and increased levels of vimentin, N-cadherin, and Snail in CNE-1 cells. The quantification of experiments was shown in right panel and data are presented as the mean ± SEM based on at least three independent experiments. *, indicated P<0.05.