Table 2.
Effect of PROG on BBB permeability and brain tissue water content in brain tissue of neonatal rats (x̅ ± s)
| EB (μg/g) | WC (%) | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Control | HI | PROG | Control | HI | PROG | |
| 6 h | 15.68 ± 5.31 | 48.56 ± 5.84* | 33.22 ± 7.08* | 85.67 ± 7.02 | 88.64 ± 5.26 | 87.49 ± 5.73 |
| 24 h | 95.47 ± 12.76* | 45.71 ± 6.27Δ | 92.75 ± 7.24* | 88.05 ± 8.43Δ | ||
| 72 h | 122.76 ± 8.90* | 96.08 ± 5.36Δ | 99.67 ± 8.07* | 91.19 ± 5.68Δ | ||
| 7 d | 23.64 ± 6.43 | 21.94 ± 4.82 | 87.15 ± 6.37 | 86.49 ± 6.58 | ||
*
P < 0.05 vs. control group;
Δ
P < 0.05 vs. hypoxic-ischaemic group at the corresponding times.