Table 2.
Univariate analysis of factors associated with OS and DFS
| OS | DFS | |||||
|---|---|---|---|---|---|---|
|
|
||||||
| P value | HR | 95% CI | P value | HR | 95% CI | |
| Gender | 0.624 | 0.439 | ||||
| Male | 1.000 | Ref. | 1.000 | Ref. | ||
| Female | 0.624 | 0.850 | 0.444-1.628 | 0.439 | 0.775 | 0.406-1.478 |
| Median age (range) | 0.763 | 0.996 | 0.967-1.025 | 0.768 | 0.996 | 0.969-1.024 |
| Smoking | 0.020 | 0.011 | ||||
| Non-heavy smoker | 1.000 | Ref. | 1.000 | Ref. | ||
| Heavy smoker | 0.020 | 1.850 | 1.103-3.106 | 0.011 | 1.933 | 1.166-3.206 |
| Alcohol intake | 0.747 | 0.940 | ||||
| Non or light | 1.000 | Ref. | 1.000 | Ref. | ||
| Heavy | 0.747 | 1.086 | 0.657-1.796 | 0.940 | 1.019 | 0.624-1.663 |
| Diameter | 0.040 | 0.033 | ||||
| <3 cm | 1.000 | Ref. | 1.000 | Ref. | ||
| ≥3 cm | 0.040 | 2.277 | 1.037-5.001 | 0.033 | 2.235 | 1.066-4.685 |
| TNM stage | 0.001 | <0.001 | ||||
| I | 1.000 | Ref. | 1.000 | Ref. | ||
| II | 0.069 | 3.039 | 0.917-10.075 | 0.064 | 3.106 | 0.937-10.294 |
| III | 0.002 | 1.328 | 1.929-20.761 | 0.001 | 7.704 | 2.356-25.199 |
| IV | 0.003 | 8.952 | 2.126-37.686 | <0.001 | 11.955 | 2.963-48.236 |
| Treatment regimen | <0.001 | 0.002 | ||||
| Surgery only | 1.000 | Ref. | 1.000 | Ref. | ||
| Surgery plus postoperative R | 0.291 | 1.424 | 0.739-2.747 | 0.194 | 1.516 | 0.809-2.839 |
| Surgery plus postoperative C | <0.001 | 4.292 | 2.181-8.445 | <0.001 | 3.726 | 1.903-7.293 |
| Surgery plus postoperative CRT | 0.067 | 1.935 | 0.954-3.923 | 0.054 | 1.961 | 0.989-3.890 |
OS: overall survival; DFS: disease-free survival; R: radiotherapy; C: chemotherapy; CRT: chemoradiotherapy.