Table 3.
MTHFR haplotype frequencies (%) in cases and controls and risk of GCA
| Haplotypes | Cases (n = 660) | Controls (n = 1216) | Crude OR (95% CI) | P | ||
|---|---|---|---|---|---|---|
|
| ||||||
| n | % | n | % | |||
| Grs4845882Ars4846048Trs1801133Trs9651118Ars3753584 | 273 | 41.36 | 528 | 43.42 | 1.00 | |
| Grs4845882Ars4846048Crs1801133Crs9651118Ars3753584 | 210 | 31.82 | 407 | 33.47 | 1.00 (0.80-1.25) | 0.985 |
| Ars4845882Grs4846048Crs1801133Trs9651118Ars3753584 | 64 | 9.70 | 118 | 9.70 | 1.05 (0.75-1.47) | 0.780 |
| Ars4845882Ars4846048Crs1801133Trs9651118Grs3753584 | 42 | 6.36 | 73 | 6.00 | 1.11 (0.74-1.67) | 0.607 |
| Grs4845882Ars4846048Crs1801133Trs9651118Ars3753584 | 27 | 4.09 | 48 | 3.95 | 1.09 (0.66-1.78) | 0.738 |
| Grs4845882Ars4846048Trs1801133Crs9651118Ars3753584 | 22 | 3.33 | 8 | 0.66 | 5.32 (2.34-12.10) | < 0.0001 |
| Ars4845882Ars4846048Crs1801133Crs9651118Ars3753584 | 7 | 1.06 | 7 | 0.58 | 1.93 (0.67-5.57) | 0.222 |
| Grs4845882Ars4846048Trs1801133Trs9651118Grs3753584 | 5 | 0.76 | 0 | 0.00 | — | 0.980 |
| Ars4845882Ars4846048Crs1801133Trs9651118Ars3753584 | 3 | 0.45 | 9 | 0.74 | 0.65 (0.17-2.40) | 0.513 |
| Ars4845882Grs4846048Crs1801133Trs9651118Grs3753584 | 2 | 0.30 | 0 | 0.00 | — | 0.981 |
| Grs4845882Ars4846048Crs1801133Trs9651118Grs3753584 | 0 | 0.00 | 4 | 0.33 | — | 0.983 |
| Ars4845882Ars4846048Trs1801133Trs9651118Ars3753584 | 2 | 0.30 | 3 | 0.25 | 1.29 (0.21-7.76) | 0.781 |
| Ars4845882Grs4846048Crs1801133Crs9651118Ars3753584 | 0 | 0.00 | 3 | 0.25 | — | 0.978 |
| Grs4845882Grs4846048Trs1801133Trs9651118Ars3753584 | 0 | 0.00 | 3 | 0.25 | — | 0.978 |
| others | 3 | 0.45 | 5 | 0.41 | 1.16 (0.28-4.89) | 0.839 |
With the order of MTHFR rs4845882 G>A, rs4846048 A>G, rs1801133 C>T, rs9651118 T>C and rs3753584 A>G in gene position.