Table 1.
Characteristics of subjects by eGFR (mL/min/1.73 m2) status (n=3876)
| All | eGFR ≥60 | eGFR <60 | p value | |
|---|---|---|---|---|
| Men | ||||
| n | 2260 (100) | 1892 (83.7) | 368 (16.3) | |
| Age (years) | 51.8±12.2 | 49.6±11.3 | 63.4±9.9 | <0.001 |
| BMI (kg/m2) | 24.5±3.2 | 24.5±3.2 | 24.7±3.0 | 0.33 |
| Systolic BP (mmHg) | 123±18 | 122±17 | 130±20 | <0.001 |
| Diastolic BP (mmHg) | 77±12 | 76±11 | 79±12 | <0.001 |
| Fasting glucose (mmol/L) | 5.22 (4.89-5.72) | 5.22 (4.89-5.67) | 5.33 (4.94-5.78) | 0.09 |
| Total cholesterol (mmol/L) | 5.05±0.94 | 5.05±0.94 | 5.09±0.92 | 0.47 |
| Triglyceride (mmol/L) | 1.32 (0.90-1.93) | 1.33 (0.90-1.95) | 1.28 (0.88-1.80) | 0.21 |
| HDL-C (mmol/L) | 1.34±0.34 | 1.35±0.33 | 1.33±0.37 | 0.42 |
| AST (U/L) | 23 (20-29) | 23 (20-29) | 24 (20-29) | 0.78 |
| ALT (U/L) | 25 (19-37) | 26 (19-38) | 23 (17-32) | <0.001 |
| Creatinine (μmol/L) | 103.7±22.9 | 98.3±10.9 | 131.4±41.1 | <0.001 |
| Uric acid (μmol/L) | 416.3±93.0 | 410.0±91.2 | 448.4±95.4 | <0.001 |
| Previous stroke | 16 (0.7) | 8 (0.4) | 8 (2.2) | 0.002 |
| Previous myocardial infarction | 43 (1.9) | 29 (1.5) | 14 (3.8) | 0.007 |
| Medication for hypertension | 317 (14.0) | 207 (10.9) | 110 (29.9) | <0.001 |
| Medication for diabetes | 108 (4.8) | 94 (5.0) | 14 (3.8) | 0.41 |
| Medication for hyperlipidemia | 54 (2.4) | 41 (2.2) | 13 (3.5) | 0.17 |
| Medication for hyperuricemia | 73 (3.2) | 39 (2.1) | 34 (9.2) | <0.001 |
| Analgesics | 48 (2.1) | 36 (1.9) | 12 (3.3) | 0.15 |
| Smoking* | 725 (34.3) | 642 (36.0) | 83 (24.9) | <0.001 |
| Habitual alcohol consumption* | 447 (22.5) | 399 (23.6) | 48 (16.4) | 0.009 |
| Total bilirubin (μmol/L) | 14.63±6.61 | 14.77±6.58 | 13.88±6.70 | 0.02 |
| Women | ||||
| n | 1616 (100) | 1465 (90.7) | 151 (9.3) | |
| Age (years) | 49.3±11.8 | 48.0±11.3 | 61.5±8.8 | <0.001 |
| BMI (kg/m2) | 23.4±3.4 | 23.3±3.3 | 24.8±3.8 | <0.001 |
| Systolic BP (mmHg) | 119±19 | 117±18 | 135±24 | <0.001 |
| Diastolic BP (mmHg) | 73±12 | 73±11 | 79±12 | <0.001 |
| Fasting glucose (mmol/L) | 5.06 (4.78-5.44) | 5.06 (4.72-5.44) | 5.22 (4.94-5.72) | <0.001 |
| Total cholesterol (mmol/L) | 5.02±0.93 | 4.98±0.91 | 5.31±1.02 | <0.001 |
| Triglyceride (mmol/L) | 0.95 (0.68-1.44) | 0.93 (0.67-1.39) | 1.37 (0.86-1.89) | <0.001 |
| HDL-C (mmol/L) | 1.64±0.40 | 1.65±0.40 | 1.57±0.42 | 0.03 |
| AST (U/L) | 20 (17-24) | 20 (17-24) | 22 (19-29) | <0.001 |
| ALT (U/L) | 17 (13-24) | 17 (13-24) | 19 (15-28) | 0.01 |
| Creatinine (μmol/L) | 78.8±37.8 | 74.3±9.0 | 122.5±111.6 | <0.001 |
| Uric acid (μmol/L) | 322.2±79.2 | 314.8±74.0 | 395.0±91.5 | <0.001 |
| Previous stroke | 10 (0.6) | 5 (0.3) | 5 (3.3) | 0.001 |
| Previous myocardial infarction | 12 (0.7) | 8 (0.5) | 4 (2.6) | 0.02 |
| Medication for hypertension | 175 (10.8) | 121 (8.3) | 54 (35.8) | <0.001 |
| Medication for diabetes | 45 (2.8) | 30 (2.0) | 15 (9.9) | <0.001 |
| Medication for hyperlipidemia | 18 (1.1) | 13 (0.9) | 5 (3.3) | 0.02 |
| Medication for hyperuricemia | 11 (0.7) | 5 (0.3) | 6 (4.0) | <0.001 |
| Analgesics | 54 (3.3) | 48 (3.3) | 6 (4.0) | 0.82 |
| Smoking* | 66 (4.6) | 64 (4.9) | 2 (1.6) | 0.14 |
| Habitual alcohol consumption* | 46 (3.7) | 45 (3.9) | 1 (1.0) | 0.17 |
| Total bilirubin (μmol/L) | 11.42±5.08 | 11.53±5.02 | 10.41±5.55 | 0.01 |
Values are expressed as mean ± standard deviation, median (interquartile range) and number (percentage). BMI, body mass index; BP, blood pressure; HDL-C, high-density lipoprotein cholesterol. AST, aspartate aminotransferase; ALT, alanine aminotransferase. p values were determined by chi-square analysis, unpaired t-test or Mann-Whitney U test.
*
Some data on smoking (n=341, M:F=145:196) and alcohol consumption (n=633, M:F=277:356) were missing.