Table 3.
Odds ratios for renal insufficiency (eGFR<60 mL/min/1.73 m2)
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
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|
|
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| Variable | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p |
| Men | ||||||
| Age (years) | 1.13 (1.11~1.15) | <0.001 | 1.12 (1.11~1.14) | <0.001 | 1.13 (1.11~1.14) | <0.001 |
| Low HDL-C | 1.73 (1.13~2.63) | 0.01 | 1.79 (1.14~2.83) | 0.01 | 1.67 (1.05~2.65) | 0.03 |
| Diabetes mellitus | 0.47 (0.29~0.77) | 0.003 | 0.46 (0.27~0.77) | 0.003 | 0.48 (0.28~0.80) | 0.005 |
| Hyperuricemia | 3.08 (2.25~4.21) | <0.001 | 3.18 (2.29~4.40) | <0.001 | 3.21 (2.31~4.46) | <0.001 |
| Habitual alcohol consumption | 0.66 (0.45~0.98) | 0.04 | 0.69 (0.46~1.02) | 0.06 | 0.67 (0.45~1.00) | 0.05 |
| Total bilirubin (μmol/L) | ||||||
| Q1 (≤8.55) | 1 (reference) | 1 (reference) | 1 (reference) | |||
| Q2 (8.56-11.97) | 0.73 (0.48~1.12) | 0.15 | 0.77 (0.50~1.21) | 0.26 | 0.86 (0.55~1.35) | 0.50 |
| Q3 (11.98-15.39) | 0.50 (0.32~0.81) | 0.004 | 0.50 (0.30~0.81) | 0.005 | 0.55 (0.33~0.90) | 0.02 |
| Q4 (>15.39) | 0.49 (0.32~0.74) | 0.001 | 0.54 (0.34~0.84) | 0.006 | 0.60 (0.38~0.94) | 0.03 |
| Women | ||||||
| Age (years) | 1.11 (1.08~1.14) | <0.001 | 1.11 (1.08~1.14) | <0.001 | 1.11 (1.08~1.14) | <0.001 |
| Hypertension | 2.01 (1.21~3.33) | 0.007 | 1.94 (1.15~3.29) | 0.01 | 1.61 (0.94~2.76) | 0.08 |
| Previous CVD | 4.48 (1.36~14.71) | 0.01 | 4.90 (1.49~16.08) | 0.009 | 5.37 (1.63~17.69) | 0.006 |
| Hyperuricemia | 4.08 (2.48~6.71) | <0.001 | 4.40 (2.62~7.39) | <0.001 | 3.91 (2.31~6.61) | <0.001 |
| Total bilirubin (μmol/L) | ||||||
| Q1 (≤6.84) | 1 (reference) | 1 (reference) | 1 (reference) | |||
| Q2 (6.85-10.26) | 0.43 (0.23~0.78) | 0.006 | 0.41 (0.22~0.75) | 0.004 | 0.49 (0.26~0.91) | 0.03 |
| Q3 (10.27-13.68) | 0.32 (0.16~0.66) | 0.002 | 0.31 (0.15~0.66) | 0.002 | 0.36 (0.17~0.78) | 0.009 |
| Q4 (>13.68) | 0.35 (0.17~0.70) | 0.003 | 0.35 (0.17~0.74) | 0.006 | 0.42 (0.20~0.90) | 0.03 |
Multivariable logistic regression adjusted for age, BMI, smoking, alcohol use, bilirubin quartiles, hypercholesterolemia, hypertriglyceridemia, low HDL-C, anti-hyperlipidemic medications, hypertension, diabetes, hyperuricemia, and previous CVD. OR, odds ratio. Model 1: all included participants in Table 1. Model 2: model 1, but excluded participants with possible liver disease (n=323, M: F=257:66). Model 3: model 2, but excluded participants with CKD stage 4 and 5 (n=12, M: F=6:6).