Table 4.
Literature retrospection of hMLH1 effect on sporadic colorectal cancer
| Country | n | MMR | Aberrant rate (%) | Selection of patients | Prognostic factor | |
|---|---|---|---|---|---|---|
| Cawkwell. 1999 | UK | 99 | hMLH1 hMSH2 | 15.15 | sporadic colorectal cancers | Yes |
| Kruschewski. 2002 | Germany | 127 | hMLH1 hMSH2 | 11.81 | sporadic colorectal cancers | No |
| Smyth. 2004 | UK | 111 | hMLH1 | 28.83 | right hemicolon cancer | Yes |
| Lanza. 2006 | Italy | 718 | hMLH1 hMSH2 | 15.88 | stageII, IIIcolorectal cancer | Yes |
| Park. 2010 | Korea | 318 | hMLH1 hMSH2 | 11.32 | sporadic colorectal cancers | Yes |
| Yoon. 2011 | Korea | 2028 | hMLH1 hMSH2 | 10.21 | sporadic colorectal cancers | DFS, Yes; OS, No |
| Aparicio. 2013 | France | 91 | MMR | 28.57 | colorectal cancer, ≥75 y, staging II | Yes |