Rules of ENS cell aggregation Adhesive capacity rule, whereby ENS agents have an adhesive potential for their ENS neighbors. Adhesion differential rule, whereby this adhesive capacity is greater for neuron agents than for ENC agents. Developmental stage rule, whereby the adhesive capacity increases gradually in both neurons and ENC agents. Neighbor-sensing rule, whereby ENS agents survey their immediate neighboring agents to detect adhesive opportunities. Movement rule, whereby ENC and neuron movement is biased towards an adjacent position that offers a more preferred (higher) adhesive capacity.