Table 1.

Green tea catechin and vitamin C supplementation and sample collection protocol.

Time point	Protocol
Day −2	24 h urine collection (baseline)
Assess MED and apply 3× MED for UVR exposed samples
Day −1	Suction blister (1× no UVR, 1× 3× MED UVR)
Punch biopsy (1× no UVR, 1× 3× MED UVR)
Day 0 (supplementation period commenced)	24 h urine collection (postingestion)
Plasma pharmacokinetics
(preingestion: 0 h)
(postingestion: 0.5, 1, 1.5, 2, 4, 6 h)
24 h urine collection
Week 6	24 h urine collection
Week 12, day −1	Apply 3× MED UVR
Week 12	Suction blister (1× no UVR, 1× 3× MED UVR; initiated 1 h and samples obtained ~3 h postingestion)
Punch biopsy (1× no UVR, 1× 3× MED UVR; samples obtained 3 h postingestion)
Plasma collection (3 h postingestion)