Table 1.

Breast cancer features in younger patients

Incidence	More common in older women. 4.5% incidence in women age <40138
Presentation	More advanced in younger women, more diagnostic delays10,11
Biology	High frequency of HR-negative disease29
Genetics	As younger women are more likely to have inherited susceptibility, genetic testing is recommended for all patients ≤40 years
Prognosis	Inferior outcome in younger patients45,57,58
Unique considerations	Premature ovarian failure, reduced fertility, increased social stressors from raising young children and active workforce participation, prolonged survivorship period, bone loss

Abbreviation: HR, hormone receptor.