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Biological characterization of AP+ I-MEFs and A375 cells. The proliferation (A) and CFA (B) of I-MEFs are reduced by fludarabine, whereas the frequency of AP+ I-MEF colonies is higher in treated cells than in untreated cells (C). The proliferation (D) and CFA (E) of A375 cells are reduced by fludarabine, whereas the frequency of AP+ A375 colonies is higher in treated cells than in untreated cells (F).
