Fig 6. Activity of anti-fungal imidazole CYP450 inhibitors on larval and adult Schistosoma mansoni worms.
Survival of schistosomula (A) after 2 d culture and adult worms (B) after 5 d culture for miconazole (black diamond), clotrimazole (black square), and ketoconazole (black triangle). (C) In house SAR on known miconazole analogs against adult worms. Numbers in the parenthesis are survival (%) of adult worms on day 7 in 10 μM of respective compound.