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. 2015 Dec 21;10:43–52. doi: 10.2147/DDDT.S93545

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© 2016 Tran et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Schematic diagram representing aberrant signaling pathways responsible for resistance to BRAF or MEK inhibitors in metastatic melanoma and pharmacological strategies to overcome this resistance.

Notes: Briefly, the molecular mechanisms of resistance to BRAF or MEK inhibitors in metastatic melanoma are highlighted. Pharmacological agents targeting key factors of these pathways undergoing clinical trials are listed.

Abbreviations: PDGFR, platelet-derived growth factor receptor; IGF, insulin-like growth factor; ERK, extracellular-signal-regulated kinase.