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. 2015 Dec 29;10(12):e0145689. doi: 10.1371/journal.pone.0145689

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© 2015 Chrzanowska-Wodnicka et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — Stereoscopic images from two (A-C; D-F) of eight analyzed pregnancies resulting from Rap1a ^+/-, Rap1b ^+/- intercrosses. About 80% of Rap1a ^-/- ; Rap1b ^-/- embryos (A, B, D) fail to develop and pregnancy products are grossly malformed and non-viable. (E) Deletion of both Rap1b and one Rap1a allele leads to severe growth restriction; (C, F) littermate Rap1a ^+/-, Rap1b ^+/+ controls. Scale bar: 0.5 mm.