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A native hepatectomy specimen from a 27-year-old male with vanishing bile duct syndrome due to allopurinol. This patient required liver transplantation 10 months after clinical presentation. A histologic section of the liver demonstrates a paucity of interlobular bile ducts. Two portal tracts shown here are devoid of interlobular bile ducts. Overall, approximately two-thirds of the small portal tracts showed bile duct loss (H&E stain, ×200).
P, portal tract.
