Table 2.
Depth of Tumor Invasion, Based on Conventional Endoscopy and Endoscopic Ultrasonography
| Endoscopic depth diagnosis | EUS depth diagnosis | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Mucosa (n=253) | Indeterminate (n=56) | Submucosa (n=84) | Mucosa-sm1 (n=214) | Submucosa (sm2) (n=166) | Proper muscle (n=13) | |
| Histologic invasion depth | ||||||
| Mucosa-sm1 (n=302) | 223 | 34 | 45 | 202 | 96 | 4 |
| Submucosa 2 (n=71) | 28 | 18 | 25 | 12 | 55 | 4 |
| Proper muscle (T2) (n=20) | 2 | 4 | 14 | 0 | 15 | 5 |
| Overall accuracy | 248/337* | 73.6 (68.9–78.3) | 262/393 | 66.7 (62.0–71.3) | ||
| Accuracy (T1m†) | 262/337* | 77.7 (73.3–82.2) | 281/393 | 71.5 (67.0–76.0) | ||
| Overestimation | 45/337* | 13.4 (9.7–17.0) | 104/393 | 26.5 (22.1–30.8) | ||
| Underestimation | 44/337* | 13.1 (9.5–16.7) | 27/393 | 6.9 (4.4–9.4) | ||
| Sensitivity (T1m†) | 223/268 | 83.2 (78.7–87.7) | 202/302 | 66.9 (61.6–72.2) | ||
| Specificity (T1m†) | 39/69 | 56.5 (44.8–68.2) | 79/91 | 86.8 (79.9–93.8) | ||
| PPV (T1m†) | 223/253 | 88.1 (84.2–92.1) | 202/214 | 94.4 (91.3–97.5) | ||
| NPV (T1m†) | 39/84 | 46.4 (35.8–57.1) | 79/179 | 44.1 (36.9–51.4) | ||
Data are presented as number or % (95% confidence interval).
EUS, endoscopic ultrasonography; PPV, positive predictive value; NPV, negative predictive value.
*
Excludes 56 indeterminate cancers for calculation;
†
T1m represents mucosal or minute submucosal (sm1) cancer on endoscopic and EUS-based depth evaluations.