Fig. 1.

Kinetics of biochemical markers during the induction of hepatic damage with carbon tetrachloride (CCl4). (A) In contrast to the 100% survival in the control group, 70% and 50% survival was observed in the 50CCl4 and 100CCl4 groups, respectively. (B) An increase in the plasmatic activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was observed during treatment with CCl4 (at both doses). (C) A significant decrease in plasmatic albumin was detected at 12 and 16 weeks in both the 50CCl4 and 100CCl4 animals compared with the control. (D) A significant increase in total bilirubin was found in CCl4-treated animals, which revealed a cirrhotic process. Values are represented as the mean±SD. *p<0.05.