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. 2016 Jan 1;27(1):1–6. doi: 10.1091/mbc.E15-06-0352

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© 2016 Shekhar and Carlier. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — ADF enhances filament turnover rate. ADF enhances the rate-limiting of step of filament depolymerization during the treadmilling cycle. It does so by cooperatively binding the ADP–F-actin subunits and enhancing their disassembly at pointed ends by destabilizing actin–actin bonds in the filament. Similarly, ADF enhances spontaneous filament fragmentation. As a result of enhanced depolymerization, ADF enhances the stationary pool of monomeric ATP–actin, leading to a faster elongation rate.