FIGURE 3:

Quantitative relationship between the YMC and CDC. (A) Plots of YMC period (τ_ymc; black dots), time spent in HOC (τ_hoc; red dots), and time spent in LOC (τ_loc; blue dots) as a function of CDC period (τ_cdc) for CEN.PK, DBY12007, YJM128 (lung), and YPS670 (oak). For clarity, we plot the mean and SD of time-series averages at identical dilution rates, which were measured during separate chemostat runs. We used nonlinear regression to best fit a mixed model to each data set; see Materials and Methods and Supplemental Figures S2 and S3. (B) Plot of YMC frequency (f_ymc = 1/τ_ymc) and CDC frequency (f_cdc = 1/τ_cdc) for all strains. (C) Metabolic profile of oxygen consumption (QO₂) and carbon dioxide production (QCO₂) of yeast strain LBGH1022 at different dilution rates from previous literature (Kaspar von Meyenburg, 1969). There is a transition from oxidative respiration (QCO₂ is equal to QO₂) to aerobic fermentation (QCO₂ is greater than QO₂) at a critical dilution rate, D_c ≈ 0.24 h⁻¹, which corresponds to the dilution rates at which our tested strains are extrapolated to spend all their time in HOC phase (colored arrows) and not oscillate.