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. 2015 Dec 29;11(12):e1005751. doi: 10.1371/journal.pgen.1005751

Fig 5. Promoter replacement reveals contributions of individual regulatory regions.

Fig 5

A. Illustration of our promoter replacement strategy. Green promoters on the left are from Sc, blue promoters on the right are from Sp. B. RNA-seq in the Sc/Sp hybrid, which measures the overall cis-regulatory divergence between these strains, is in approximate agreement with the effect of the promoter replacements, measured by qPCR (r = 0.92). Error bars show 1 S.E. C. After competitive growth for 40 generations, promoter replacement strains for 3/4 candidate genes show a similar pattern of fitness advantage in the presence of 300 ppm citrinin, and disadvantage in its absence. Error bars show 1 S.E.