Table 2. The twenty most significant pathways affected by siQI transfection in BJAB Burkitt's cells.
| Rank | Ingenuity Canonical Pathways | P-value | Transcripts |
|---|---|---|---|
| 1 | Dendritic Cell Maturation | 2.69E-05 | COL1A1, CD80, PIK3CG, IL32, FSCN1, AKT3, LTB, IL1B, TLR3, CCR7 |
| 2 | Lymphotoxin β Receptor Signaling | 3.02E-04 | VCAM1, PIK3CG, AKT3, LTB, TRAF1 |
| 3 | Crosstalk between Dendritic Cells and Natural Killer Cells | 4.57E-04 | CD80, CD69, FSCN1, LTB, TLR3, CCR7 |
| 4 | NF-κB Signaling | 4.90E-04 | TGFBR1, HDAC2, PIK3CG, IGF1R, AKT3, IL1B, TLR3, TNFRSF17 |
| 5 | Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis | 5.50E-04 | VCAM1, C5AR1, PIK3CG, IL32, RAC1, AKT3, LTB, IL1B, TLR3, WNT5A, TRAF1 |
| 6 | Docosahexaenoic Acid (DHA) Signaling | 8.51E-04 | PIK3CG, AKT3, IL1B, APP |
| 7 | Hepatic Fibrosis / Hepatic Stellate Cell Activation | 8.51E-04 | COL1A1, VCAM1, TGFBR1, TIMP1, IGF1R, IL1B, CCR7 |
| 8 | Role of Tissue Factor in Cancer | 1.38E-03 | PIK3CG, EGR1, RAC1, ITGA6, AKT3, IL1B |
| 9 | Altered T Cell and B Cell Signaling in Rheumatoid Arthritis | 2.51E-03 | CD80, LTB, IL1B, TLR3, TNFRSF17 |
| 10 | RAR Activation | 3.09E-03 | GNAS, DHRS9, PIK3CG, RAC1, AKT3, SMAD5, RXRA |
| 11 | Communication between Innate and Adaptive Immune Cells | 3.24E-03 | CD80, IL1B, TLR3, CCR7, TNFRSF17 |
| 12 | Human Embryonic Stem Cell Pluripotency | 3.55E-03 | GNAS, TGFBR1, PIK3CG, AKT3, SMAD5, WNT5A |
| 13 | Regulation of the Epithelial-Mesenchymal Transition Pathway | 3.80E-03 | TGFBR1, PIK3CG, EGR1, ZEB2, PARD6B, AKT3, WNT5A |
| 14 | Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 4.07E-03 | CLEC7A, C5AR1, PIK3CG, IL1B, TLR3 |
| 15 | CXCR4 Signaling | 6.76E-03 | MYL12A, GNAS, PIK3CG, EGR1, RAC1, AKT3 |
| 16 | Sphingosine-1-phosphate Signaling | 7.24E-03 | GNAS, PIK3CG, RAC1, AKT3, ASAH1 |
| 17 | Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency | 7.41E-03 | PIK3CG, AKT3, SMAD5, WNT5A, TCL1A |
| 18 | Small Cell Lung Cancer Signaling | 7.59E-03 | PIK3CG, AKT3, RXRA, TRAF1 |
| 19 | NF-κB Activation by Viruses | 8.71E-03 | PIK3CG, ITGA6, AKT3, CXCR5 |
| 20 | PTEN Signaling | 9.33E-03 | TGFBR1, PIK3CG, IGF1R, RAC1, AKT3 |
Transcripts whose levels also changed in MEC2 CLL cells are given in bold letters.