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. 2015 May 4;6(28):24690–24698. doi: 10.18632/oncotarget.3992

Figure 1. The boxplots show mRNA expression of CDK2, CDK6, CCND1 and CDKN2A in neuroendocrine tumors of the lung.

Figure 1

On the x-axis the tumor subtype is shown and the y-axis indicates the amount of detected mRNA transcripts. CDK2 expression was higher in high-grade NET with highest expression in SCLC, whereas CDK6 showed significantly higher expression in carcinoids than in carcinomas. CCND1 expression decreased from TC to SCLC. CDKN2A was identified as prominent marker for aggressiveness of the tumor. Only high-grade tumors and aggressive carcinoids showed elevated CDKN2A expression.