Table 3. Multivariate analysis of clinicopathological factors for PFS in patients with IDH mutated (n = 215) and IDH wild-type (n = 77) WHO II and III diffuse gliomas.

IDH, TERT promoter and 1p/19q codeletion status	Variables	PFS		OS
		HR(95%CI)	p-value	HR(95%CI)	p-value
IDH mut	Age	1.011(0.990–1.031)	0.302	1.019(0.996–1.043)	0.105
	WHO grade (Grade II vs III)	1.720(1.030–2.873)	0.038	1.884(1.059–3.354)	0.031
	Complete resection (Yes vs. No)	2.399(1.559–3.691)	<0.001	1.960(1.212–3.169)	0.006
	RT (Yes vs. No)	2.345(1.409–3.904)	0.001	2.001(1.136–3.526)	0.016
	CHT (Yes vs. No)	1.646 (1.062–2.552)	0.026	1.295(0.781–2.149)	0.316
	1p/19q codeletion (Yes vs. No)	1.747(1.109–2.751)	0.016	2.142(1.270–3.612)	0.004
IDH wt	Age	1.028(1.005–1.052)	0.017	1.023(0.999–1.048)	0.056
	WHO grade (Grade II vs III)	4.030(1.978–8.208)	<0.001	4.113(1.910–8.858)	<0.001
	Complete resection (Yes vs. No)	2.398(0.908–6.330)	0.077	2.825(1.072–7.445)	0.036
	RT (Yes vs. No)	1.349(0.698–2.607)	0.373	1.367(0.701–2.667)	0.36
	CHT (Yes vs. No)	1.211(0.440–3.329)	0.711	0.903(0.339–2.400)	0.837
TERT mut	Age	1.057(1.027–1.088)	<0.001	1.085(1.047–1.125)	<0.001
	WHO grade (Grade II vs III)	2.214(1.150–4.262)	0.017	2.413(1.141–5.104)	0.021
	Complete resection (Yes vs. No)	2.387(1.307–4.358)	0.005	2.206(1.027–3.998)	0.042
	RT (Yes vs. No)	2.211(1.118–4.371)	0.022	2.292(1.055–4.978)	0.036
	CHT (Yes vs. No)	1.000(0.528–1.896)	1	0.577(0.271–1.230)	0.155
	1p/19q codeletion (Yes vs. No)	1.639(0.900–2.985)	0.107	2.209(1.028–4.004)	0.041
TERT wt	Age	1.022(1.005–1.039)	0.011	1.022(1.003–1.041)	0.02
	WHO grade (Grade II vs III)	2.87(1.755–4.692)	<0.001	3.282(1.930–5.579)	<0.001
	Complete resection (Yes vs. No)	1.967(1.241–3.118)	0.004	1.856(1.128–3.054)	0.015
	RT (Yes vs. No)	1.477(0.896–2.434)	0.126	1.551(0.917–2.622)	0.101
	CHT (Yes vs. No)	1.593 (0.991–2.561)	0.055	1.350(0.810–2.250)	0.249
	1p/19q codeletion (Yes vs. No)	2.085(0.898–4.844)	0.087	2.964(1.068–8.228)	0.037
1p/19q codeletion	Age	1.045(1.003–1.089)	0.036	1.066(1.010–1.125)	0.021
	WHO grade (Grade II vs III)	1.891(0.681–5.253)	0.221	2.448(0.777–7.708)	0.126
	Complete resection (Yes vs. No)	2.908(1.258–6.723)	0.013	3.167(1.207–8.310)	0.019
	RT (Yes vs. No)	2.404(0.953–6.066)	0.063	1.471(0.460–4.702)	0.515
	CHT (Yes vs. No)	1.526 (0.681–3.419)	0.304	0.798(0.277–2.302)	0.677
	1p/19q codeletion (Yes vs. No)	1.054(0.416–2.667)	0.912	0.810(0.267–2.460)	0.71

p values in bold were considered statistically significant

IDH mut: IDH mutant; IDH wt: IDH wild-type; HR: hazard ratio; CI: confidence interval; RT: radiation therapy; CHT: chemotherapy.