Figure 1. Effect of azathioprine treatment on survival, lymphoma incidence and MSI tumor phenotype in Msh2^+/− and Msh2^ko mice.

A. Evidence for a dose-response relationship between azathioprine treatment and the survival of Msh2^+/– mice: Kaplan–Meier survival analysis of untreated and azathioprine-treated Msh2^+/– mice (left) and Msh2^ko mice (right). Survival curves for Msh2^+/– mice after Aza50 treatment are from our previous study [9]. All P values are two-sided. Log-rank test. B. Lymphoma occurrence and delay of onset in the different mice cohorts according to Msh2^+/– (left) or Msh2^ko (right) genotype. Mean age of lymphoma onset and standard error of the mean are indicated. C. Evidence for a dose-response relationship between azathioprine treatment and incidence of MSI phenotype in lymphomas of Msh2^+/– mice. Aza10 = azathioprine 10 mg/L; Aza30 = azathioprine 30 mg/L; Aza50 = azathioprine 50 mg/L.