Figure 2. Effect of azathioprine and ciclosporin A treatments on survival, lymphoma incidence and MSI tumor phenotype in Msh2^wt mice.

A. Evidence for a dose-response relationship between immunosuppressive treatment and the survival of Msh2^wt mice: Kaplan–Meier survival analysis of untreated, azathioprine- and ciclosporin A-treated Msh2^wt mice. All P values are two-sided. Log-rank test. B. Occurrence of lymphoproliferations and delay of onset in the different cohorts of Msh2^wt mice. C. Lymphoma incidence. Fisher's exact test; ns=not significant. D. Incidence of MSI phenotype in lymphomas. Aza10 = azathioprine 10 mg/L; Aza30 = azathioprine 30 mg/L; Aza50 = azathioprine 50 mg/L; CsA = ciclosporin A 300 mg/L.