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. 2015 Jun 29;6(28):25034–25045. doi: 10.18632/oncotarget.4379

Figure 2. Expression and localization of target protein transmembrane 88 (TMEM88) in breast cancer cell lines.

Figure 2

A. Analysis of TMEM88 expression patterns in the MCF-10A, MCF-7, HER18, MDA-MB-231, and MDA-MB-468 cell lines by immunofluorescence microscopy using a TMEM88-specific antibody. Cells primarily exhibited cytoplasmic localization of TMEM88, but not plasma membrane or nuclear localization. B. In the majority of breast cancer cell lines, TMEM88 expression was higher than that in the normal breast cell line MCF-10A, and lower than that in the MCF-7 cell line. The 17-kDa TMEM88 isoform was expressed at significantly higher levels in the triple-negative breast cancer cell lines (MDA-MB-231 and MDA-MB-468) than in MCF-10A cells.