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. 2015 Jul 10;6(28):25149–25160. doi: 10.18632/oncotarget.4438

Figure 2. IGF2BP3 decrease facilitated drug-resistance suppression.

Figure 2

A. Real-time PCR analysis verified the changes of the genes expression after d-ICD treatment, which was revealed by microarray, compared with the control group. The values were shown as the mean ± SD. (*p < 0.05, **p < 0.01; Student t test, vs the control group). B. Western blot analysis of the genes expression with d-ICD treatment in HCC cells. C. IGF2BP3 mRNA expression gradually decreased after exposure to 15 ug/ml d-ICD in Huh7 and 20 ug/ml d-ICD in MHCC-97L cells in a time dependent way. (*p < 0.05, **p < 0.01; Student t test, vs the cells untreated) D. Growth inhibition induced by d-ICD treatment for 24 h of HCC cells with IGF2BP3 overexpression. (*p < 0.05, **p < 0.01; Student t test, vs the cells infected with the EX-NEG vector lenti-virus) E. IGF2BP3 targeted down-regulation promoted growth inhibition induced by the treatment of d-ICD for 24 h. (*p < 0.05, **p < 0.01; Student t test, vs the cells transfected with stable negative control siRNA oligonucleotides, siNC for short).