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. 2015 Jul 23;6(28):25161–25174. doi: 10.18632/oncotarget.4629

Figure 1. Dynamical system characteristics of the EMT decision-making circuit - (miR-200/ZEB).

Figure 1

A. Nullclines of (miR-200/ZEB) circuit for SNAIL = 200 * 103 molecules representing three steady states: Epithelial (E—high miR-200, low ZEB), hybrid Epithelial/Mesenchymal (E/M—medium miR-200, medium ZEB) and Mesenchymal (low miR-200, high ZEB). Solid green dots represent stable states; hollow green dots represent unstable states. B. Bifurcation levels of mRNA levels of ZEB in response to SNAIL for miR-200/ZEB circuit. C. Bifurcation levels of mRNA levels of ZEB in response to SNAIL for miR-200/ZEB/OVOL circuit. Different phenotypes obtained at different levels of SNAIL are labeled alongside. D. Comparing the different phases (co-existence of different phenotypes) obtained for miR-200/ZEB in (B) and miR-200/ZEB/OVOL circuits in (C).