Figure 2. CDDO and CDDO-Me alter mitochondrial membrane potential (MMP).

A. Representative dot plots showing JC-1 monomers and aggregates in cells treated with DMSO (Ctrl) and increasing concentrations of CDDO or CDDO-Me. Valinomycin (Val) was used a positive control for mitochondrial depolarization. B. Quantification of cells with depolarized mitochondria. Values represent the mean ± SD of five independent experiments, *P < 0.05 and **P < 0.01 vs. Ctrl.